Progesterone and its metabolites promote the viability of neurons in the brain and spinal
cord. Their neuroprotective effects have been documented in different lesion models …

The utility and safety of postmenopausal hormone replacement therapy has recently been
put into question by large clinical trials. Their outcome has been extensively commented …

STUDY OBJECTIVE: Laboratory evidence indicates that progesterone has potent
neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential …

Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …

The spinal cord is a target of progesterone (PROG), as demonstrated by the expression of
intracellular and membrane PROG receptors and by its myelinating and neuroprotective …

Purpose: Previous studies suggest that progesterone (PROG) has a substantial protective
effect against several types of brain injury. Since most cases of human stroke are caused by …

The inflammatory cascade that follows traumatic brain injury may lead to secondary cell
death and can impede recovery of function. Complement factors and their convertases are …

The present study used the National Institute on Disability Rehabilitation and Research
(NIDRR) funded Traumatic Brain Injury Model Systems (TBIMS) database to examine the …

As epidemiological data have suggested that female patients may have improved clinical
prognoses following traumatic brain injury (TBI) compared to males, we designed …

We have previously shown that traumatic brain injury (TBI) can induce an upregulation of
nuclear factor kappa B (NF‐κB) and proinflammatory cytokines in the gut, which play an …