Many potential drugs that specifically target a particular protein considered to underlie a
given disease have been found to be less effective than hoped, or to cause significant side …

Motivation: Analogous to biological sequence comparison, comparing cellular networks is
an important problem that could provide insight into biological understanding and …

We study a map of the Internet (at the autonomous systems level), by introducing and using
the method of k-shell decomposition and the methods of percolation theory and fractal …

Effective management of critical network infrastructure requires the assessment of potential
interdiction scenarios. Optimization approaches have been essential for identifying and …

We show how preferential attachment can emerge in an optimization framework, resolving a
long-standing theoretical controversy. We also show that the preferential attachment model …

Many transport processes on networks depend crucially on the underlying network
geometry, although the exact relationship between the structure of the network and the …

This paper describes an effort to determine the rationale and content for a research agenda
in complex systems. This effort included a workshop conducted with 50 thought leaders in …

The extent to which “developmental constraints” in complex organisms restrict evolutionary
directions remains contentious. Yet, other forms of internal constraint, which have received …

A popular approach for describing the structure of many complex networks focuses on graph
theoretic properties that characterize their large-scale connectivity. While it is generally …

Neural connections of the mammalian cerebral cortex exhibit specific patterns ranging in
scale from interconnections linking whole brain regions to intraareal patterns of connections …