The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications
A Arcaro, AS Guerreiro - Current genomics, 2007 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
Pathobiology of ALK+ anaplastic large-cell lymphoma
HM Amin, R Lai - Blood, The Journal of the American Society of …, 2007 - ashpublications.org
Anaplastic large-cell lymphoma (ALCL) was initially recognized on the basis of morphologic
features and the consistent expression of CD30. It then became evident that the majority of …
features and the consistent expression of CD30. It then became evident that the majority of …
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
JG Christensen, HY Zou, ME Arango, Q Li, JH Lee… - Molecular cancer …, 2007 - AACR
Abstract A t (2; 5) chromosomal translocation resulting in expression of an oncogenic kinase
fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been …
fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been …
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
AV Galkin, JS Melnick, S Kim… - Proceedings of the …, 2007 - National Acad Sciences
Constitutive overexpression and activation of NPM-ALK fusion protein [t (2: 5)(p23; q35)] is a
key oncogenic event that drives the survival and proliferation of anaplastic large-cell …
key oncogenic event that drives the survival and proliferation of anaplastic large-cell …
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling
PB Staber, P Vesely, N Haq, RG Ott… - Blood, The Journal …, 2007 - ashpublications.org
Anaplastic large cell lymphomas (ALCLs) are highly proliferating tumors that commonly
express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of …
express the AP-1 transcription factor JunB. ALK fusions occur in approximately 50% of …
Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
M Marzec, M Kasprzycka, X Liu, M El-Salem, K Halasa… - Oncogene, 2007 - nature.com
The mechanisms of cell transformation mediated by the nucleophosmin (NPM)/anaplastic
lymphoma kinase (ALK) tyrosine kinase are only partially understood. Here, we report that …
lymphoma kinase (ALK) tyrosine kinase are only partially understood. Here, we report that …
NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma
V Leventaki, E Drakos, LJ Medeiros… - Blood, The Journal …, 2007 - ashpublications.org
Anaplastic large-cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35), resulting in
aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). We show …
aberrant expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). We show …
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at (2; 5) …
The heat‐shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein–Barr virus‐positive NK/T‐cell lymphoma by Akt down‐regulation
Abstract NK/T‐cell lymphoma (NKTL) is strongly associated with latent Epstein–Barr virus
(EBV) infection. Recently, latent membrane protein 1 (LMP1), an EBV oncoprotein, was …
(EBV) infection. Recently, latent membrane protein 1 (LMP1), an EBV oncoprotein, was …
NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma
A Galietta, RH Gunby, S Redaelli… - Blood, The Journal …, 2007 - ashpublications.org
The oncogenic fusion tyrosine kinase nucleophosmin/anaplastic lymphoma kinase
(NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas (ALCLs) …
(NPM/ALK) induces cellular transformation in anaplastic large-cell lymphomas (ALCLs) …