In the past decade, periodontal disease has been recognized as not merely a local
infectious disease, but as chronic, subclinical, inflammatory disease for the host. Diabetic …

Objectives: We hypothesized that the expansion of unusual T lymphocytes, CD4+
CD28nullT cells, might represent a key pathogenetic mechanism of recurrent instability …

To determine the role of expanded CD4+ CD28 null T cells in multiple sclerosis and
rheumatoid arthritis pathology, these cells were phenotypically characterized and their Ag …

Background Serum levels of circulating markers associated with cardiovascular morbidity
are elevated in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). These …

Different subsets of T lymphocytes have different functions in atherosclerosis advancement.
T helper 1 cells and T regulatory 1 cells have been demonstrated to play opposite roles in …

Inflammation is associated with the pathogenesis of coronary atherosclerosis, although the
mechanisms remain unclear. We investigated whether cytokine secretion by innate immune …

The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous
diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as …

Expanded populations of CD4+ T cells lacking the co-stimulatory molecule CD28 (CD4+
CD28 null T cells) have been reported in several inflammatory disorders. In rheumatoid …

AIMS: In advanced human atherosclerotic plaques infiltrating T cells congregate at sites of
plaque rupture. However, little is known about the systemic activation of circulating T cells in …

Objective In rheumatoid arthritis (RA), synovial fibroblasts proliferate excessively, eventually
eroding bone and cartilage. The aim of this study was to examine the mechanisms through …