There are two intriguing paradoxes in molecular biology—the inconsistent relationship
between organismal complexity and (1) cellular DNA content and (2) the number of protein …

Recent evidence of genome-wide transcription in several species indicates that the amount
of transcription that occurs cannot be entirely accounted for by current sets of genome-wide …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Despite the known existence of distant-acting cis-regulatory elements in the human genome,
only a small fraction of these elements has been identified and experimentally characterized …

We developed a method, ChIP-sequencing (ChIP-seq), combining chromatin
immunoprecipitation (ChIP) and massively parallel sequencing to identify mammalian DNA …

Insulator elements affect gene expression by preventing the spread of heterochromatin and
restricting transcriptional enhancers from activation of unrelated promoters. In vertebrates …

Long transcripts that do not encode protein have only rarely been the subject of
experimental scrutiny. Presumably, this is owing to the current lack of evidence of their …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum
(Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the …

Many alternative splicing events create RNAs with premature stop codons, suggesting that
alternative splicing coupled with nonsense-mediated decay (AS-NMD) may regulate gene …

The recent availability of genome-scale genotyping data has led to the identification of
regions of the human genome that seem to have been targeted by selection. These findings …