Schizophrenia is a debilitating mental illness that affects 1 percent of the population in all
cultures. It affects equal numbers of men and women, but the onset is often later in women …

The neurodevelopmental hypothesis of schizophrenia posits an interaction between multiple
susceptibility genes and one or more environmental insults in early life, resulting in altered …

We used a preparation of acutely dissociated neurons to quantify the ionic currents driving
the spontaneous firing of substantia nigra pars compacta neurons, isolated from transgenic …

Previous studies of postnatal synaptic development in human frontal cortex have shown that
synaptic density rises after birth, reaches a plateau in childhood and then decreases to adult …

Currently available laboratory procedures might provide additional information to psychiatric
diagnostic systems for more valid classifications of mental disorders. To identify the …

NMDA receptor (NMDA-R) antagonists are extensively used as schizophrenia models
because of their ability to evoke positive and negative symptoms as well as cognitive deficits …

Increasing evidence suggests that pre-or perinatal events that influence the immune system
contribute to the development of behavioral or neuropsychiatric disorders. For instance …

Context Loosening of associations has long been considered a core feature of
schizophrenia, but its neural correlate remains poorly understood. Objective To test the …

Rationale Aripiprazole is an atypical antipsychotic drug with high in vitro affinity for 5-HT 1A,
5-HT 2A and dopamine (DA) D2 receptors. However, its in vivo actions in the brain are still …

Abstract Disrupted-in-schizophrenia 1 (DISC1) is a gene disrupted by a (1; 11)(q42. 1; q14.
3) translocation that segregates with major psychiatric disorders in a Scottish family. To …