Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin,
Sir2 (silent information regulator 2) of Saccharomyces cerevisia e, from which the family …

Nicotinamide adenine dinucleotide (NAD+) is both a coenzyme for hydride-transfer enzymes
and a substrate for NAD+-consuming enzymes, which include ADP-ribose transferases, poly …

Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones …

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined
as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate …

The RNA binding protein HuR regulates the stability of many target mRNAs. Here, we report
that HuR associated with the 3′ untranslated region of the mRNA encoding the longevity …

Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …

The sirtuin family of histone deacetylases (HDACs) was named after their homology to the
Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has …

Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and
Drosophila. The NAD requirement for sirtuin function indicates a link between aging and …

Caloric restriction is the only known non-genetic intervention that robustly extends lifespan
in mammals. This regimen also attenuates the incidence and progression of many age …

The levels of oxidatively damaged, carbonylated, proteins increase with the replicative age
of yeast mother cells. We show here that such carbonylated proteins are associated with …