Toxicology can no longer be used only as a science that reacts to problems but must be
more proactive in predicting potential human safety issues with new drug candidates …

Time-dependent inhibition (TDI) of CYP refers to a change in potency during an in vitro
incubation or dosing period in vivo. Potential mechanisms include the formation of inhibitory …

The role of C239 as the active-site residue responsible for forming the covalent linkage with
raloxifene during P450 3A4 time-dependent inactivation (TDI) was recently identified. The …

Identification and elucidation of the structures of metabolites play major roles in drug
discovery and in the development of pharmaceutical compounds. These studies are also …

Determination of the chemical structures of metabolites is a critical part of the early
pharmaceutical discovery process. Understanding the structures of metabolites is useful …

Metabolites are chemical entities formed as a result of biotransformation of endogenous
compounds and xenobiotics. In general, metabolism leads to more hydrophilic species …

Drug metabolism research has become an integral part of the lead optimization phase of
drug discovery. The goal of this work is to attempt to optimize the metabolism properties of …

The use of remote sensing technology has made it possible for the non-contact
measurement of soil moisture content (SMC). Many remote sensing techniques can be used …

Haloperidol (HP), an antipsychotic agent, is used for the treatment of acute and chronic
schizophrenia and associated with extrapyramidal side effects which may be due to altered …