The severe acute respiratory syndrome coronavirus (SARS-CoV) is highly pathogenic in
humans, with a death rate near 10%. This high pathogenicity suggests that SARS-CoV has …

The severe acute respiratory syndrome (SARS) epidemic was caused by the spread of a
previously unrecognized infectious agent, the SARS-associated coronavirus (SARS-CoV) …

Conserved among all coronaviruses are four structural proteins: the matrix (M), small
envelope (E), and spike (S) proteins that are embedded in the viral membrane and the …

Both apoptosis and necrosis have been observed in cells infected by various coronaviruses,
suggesting that the regulation of cell death is important for viral replication and/or …

Manipulation of the cell cycle and induction of apoptosis are two common strategies used by
many viruses to regulate their infection cycles. In cells infected with coronaviruses, cell cycle …

The pathogenesis of severe acute respiratory syndrome coronavirus (SARS-CoV) is likely
mediated by disproportional immune responses and the ability of the virus to circumvent …

The nucleolus is a dynamic sub-nuclear structure which is involved in ribosome subunit
biogenesis, modulation of cell growth and response to cell stress. The nucleolar proteome …

p27 Kip1 is a critical regulator of the eukaryotic cell cycle. It acts as a check point proteinand
regulates cell cycle progression at the G1 and G1/S phase as well as predominantlyblocks …

After decoding the genome of SARS-coronavirus (SARS-CoV), next challenge is to
understand how this virus causes the illness at molecular bases. Of the viral structural …

The positive strand RNA coronavirus, infectious bronchitis virus (IBV), induces a G2/M phase
arrest and reduction in the G1 and G1/S phase transition regulator cyclin D1. Quantitative …