The dominant paradigm in drug discovery is the concept of designing maximally selective
ligands to act on individual drug targets. However, many effective drugs act via modulation …

Chronic adult periodontitis is a bacterially induced chronic inflammatory disease that
destroys the connective tissue and bone that support teeth. Concepts of the specific …

Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

Analyzing metabolites (small molecules< 1 kDa) in body fluids such as urine and plasma
using various spectroscopic methods provides information on the metabotype (metabolic …

The enormous complexity of the human brain ultimately derives from a finite set of molecular
instructions encoded in the human genome. These instructions can be directly studied by …

Genetic variants that are associated with common human diseases do not lead directly to
disease, but instead act on intermediate, molecular phenotypes that in turn induce changes …

Expression quantitative trait loci (eQTL) mapping studies have become a widely used tool
for identifying genetic variants that affect gene regulation. In these studies, expression levels …

A key goal of biology is to construct networks that predict complex system behavior. We
combine multiple types of molecular data, including genotypic, expression, transcription …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome …

Genome-wide association studies have successfully identified numerous loci at which
common variants influence disease risk or quantitative traits. Despite these successes, the …