Objective To aid in the timely diagnosis of patients who present with clinically isolated
syndrome (CIS). Patients and methods We studied 25 patients (18 women, 7 men), originally …

MR imaging is an integral part of multiple sclerosis (MS) clinical trials. It provides the primary
efficacy outcome of preliminary proof-of-concept studies and important corroborating data as …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system,
predominantly, but not exclusively, involving the normal appearing white matter. Until very …

Optic neuritis is an inflammation of one optic nerve, usually resulting in temporary loss of
vision. It is frequently an early clinical manifestation of multiple sclerosis (MS), meaning …

There is a need for sensitive measures of disease progression in multiple sclerosis (MS) to
monitor treatment effects and understand disease evolution. MRI measures of brain atrophy …