Most bacteria can selectively use substrates from a mixture of different carbon sources. The
presence of preferred carbon sources prevents the expression, and often also the activity, of …

Historically, the study of bacterial catabolism of complex carbohydrates has contributed to
understanding basic bacterial physiology. Recently, however, genome-wide screens of …

Although central to pathogenesis, the molecular mechanisms used by microbes to regulate
virulence factor production in specific environments during host–pathogen interaction are …

Asymptomatic colonization of the nasopharynx by Streptococcus pneumoniae precedes
pneumococcal disease, yet pneumococcal colonization factors remain poorly understood …

CcpA globally regulates transcription in response to carbohydrate availability in many gram-
positive bacteria, but its role in Streptococcus mutans remains enigmatic. Using the fructan …

Summary spxB‐encoded pyruvate oxidase is a major virulence factor of Streptococcus
pneumoniae. During aerobic growth, SpxB synthesizes H2O2 and acetyl phosphate, which …

CcpA is the global mediator of carbon catabolite repression (CCR) in gram-positive bacteria,
and growing evidence from several pathogens, including the group A streptococcus (GAS) …

Pili have been observed on the surface of several gram-positive bacteria, including
Streptococcus pneumoniae. The S. pneumoniae strain TIGR4 pilus is composed of three …

Background The catabolite control protein CcpA is a transcriptional regulator conserved in
many Gram-positives, controlling the efficiency of glucose metabolism. Here we studied the …

Avec pour point de départ une problématique de production vaccinale, une analyse
intégrative du métabolisme central et du transcriptome de S. pneumoniae en conditions …