Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
M Fulco, V Sartorelli - Cell cycle, 2008 - Taylor & Francis
The ability to adapt and respond to nutrients is an ancient cellular function, conserved from
unicellular to the most complex multicellular organisms, including mammals. Mammals …
unicellular to the most complex multicellular organisms, including mammals. Mammals …
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
The mammalian circadian timing system is composed of a central pacemaker in the
suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in …
suprachiasmatic nucleus of the brain that synchronizes countless subsidiary oscillators in …
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
M Fulco, Y Cen, P Zhao, EP Hoffman, MW McBurney… - Developmental cell, 2008 - cell.com
It is intuitive to speculate that nutrient availability may influence differentiation of mammalian
cells. Nonetheless, a comprehensive complement of the molecular determinants involved in …
cells. Nonetheless, a comprehensive complement of the molecular determinants involved in …
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
R Firestein, G Blander, S Michan, P Oberdoerffer… - PloS one, 2008 - journals.plos.org
Numerous longevity genes have been discovered in model organisms and altering their
function results in prolonged lifespan. In mammals, some have speculated that any health …
function results in prolonged lifespan. In mammals, some have speculated that any health …
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
S Rajendrasozhan, SR Yang, VL Kinnula… - American journal of …, 2008 - atsjournals.org
Rationale: Abnormal inflammation and accelerated decline in lung function occur in patients
with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging …
with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging …
Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
There is increasing evidence that longevity and stress resistance are connected, but the
mechanism is unclear. We report that mitochondria are regulated in response to oxidative …
mechanism is unclear. We report that mitochondria are regulated in response to oxidative …
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
J Pallos, L Bodai, T Lukacsovich… - Human molecular …, 2008 - academic.oup.com
Huntington's disease (HD) is associated with transcriptional dysregulation, and multiple
studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for …
studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for …
Exercise training promotes SIRT1 activity in aged rats
The objective of this study was to determine the effects of aging and exercise training on
SIRT1 activity and to identify a pathway linking SIRT1 to antioxidant response and cell cycle …
SIRT1 activity and to identify a pathway linking SIRT1 to antioxidant response and cell cycle …
Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
DM Breen, T Sanli, A Giacca, E Tsiani - Biochemical and biophysical …, 2008 - Elsevier
Although recent studies in vitro and in vivo indicate that the polyphenol resveratrol (RSV)
has anti-diabetic properties, the exact mechanisms involved are not known. In the present …
has anti-diabetic properties, the exact mechanisms involved are not known. In the present …