Malignant gliomas, the most common type of primary brain tumor in adults, are associated
with disproportionate cancer-related morbidity and mortality. Recently, there have been …

The high frequency of phosphoinositide 3-kinase (PI3K) pathway alterations in cancer has
led to a surge in the development of PI3K inhibitors. Many of these targeted therapies are …

Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and
angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To
identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes …

Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the
p110-α catalytic subunit (encoded by PIK3CA). They are most frequently observed in two …

Genomic technologies offer the promise of a comprehensive understanding of cancer.
These technologies are being used to characterize tumours at the molecular level, and …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
inhibitor (mTOR) pathway is often constitutively activated in human tumor cells, providing …

Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several
genomic alterations. There is evidence of aberrant activation of several signaling cascades …

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults.
We combined neuroimaging and DNA microarray analysis to create a multidimensional map …

The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify
promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such …