Genetic mapping provides a powerful approach to identify genes and biological processes
underlying any trait influenced by inheritance, including human diseases. We discuss the …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

We have developed a new set of algorithms, collectively called “Velvet,” to manipulate de
Bruijn graphs for genomic sequence assembly. A de Bruijn graph is a compact …

Background Transposable elements are abundant in eukaryotic genomes and it is believed
that they have a significant impact on the evolution of gene and chromosome structure …

Canonical microRNAs (miRNAs) require two processing steps: the first by the
Microprocessor, a complex of DGCR8 and Drosha, and the second by a complex of TRBP …

Identification of lineage-specific innovations in genomic control elements is critical for
understanding transcriptional regulatory networks and phenotypic heterogeneity. We …

Pharmaceuticals are typically found in very low concentrations in the aquatic environment.
Accordingly, environmental effects clearly assigned to residual drugs are consistent with …

The survival of motor neurons (SMN) protein is essential for the biogenesis of small nuclear
RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA …

Genome-wide scans for positively selected genes (PSGs) in mammals have provided insight
into the dynamics of genome evolution, the genetic basis of differences between species …

We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This
monotreme exhibits a fascinating combination of reptilian and mammalian characters. For …