Alkannins and Shikonins (A/S) are chiral-pairs of naturally occurring
isohexenylnaphthazarins. They are found in the external layer of the roots of at least a …

In this study, aloe-emodin was identified as a potential interferon (IFN)-inducer by screening
compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human …

Shikonin, a naphthoquinone pigment isolated from the Chinese herbal therapeutic, Zicao,
has been shown to exhibit antioxidant and anticancer effects. In this study, its ability to …

Lithospermum erythrorhizon has been used for treatment of in‰ ammatory diseases and
cancer as a folk remedy. Based on the evidences that anti-in‰ ammatory agents frequently …

Shikonin derivatives, which are the active components of the medicinal plant Lithospermum
erythrorhizon, exhibit many biological effects including apoptosis induction through …

This work reports the extraction procedures of alkannin/shikonin mixture from roots of six
populations of Onosma echioides, by means of three extraction techniques: Soxhlet …

Bone undergoes continuous remodeling through bone formation and resorption, and
maintaining the balance for skeletal rigidity. Bone resorption and loss are generally …

Shikonin and its derivatives are important red colored naphthoquinone pigments found in a
large number of Arnebia species, including A. euchroma, that are responsible for the various …

Objective: Shikonin, a component of the herbal medicine “Shikon”, is known to suppress
inflammatory reactions, but its molecular targets are not identified. This study examines the …

OBJECTIVES: β-Hydroxyisovalerylshikonin (β-HIVS), a compound isolated from the
traditional oriental medicinal herb Lithospermum radix, is an ATP non-competitive inhibitor …