Glutathione and apoptosis

ML Circu, T Yee Aw - Free radical research, 2008 - Taylor & Francis
Apoptosis or programmed cell death represents a physiologically conserved mechanism of
cell death that is pivotal in normal development and tissue homeostasis in all organisms. As …

Thiol chemistry in peroxidase catalysis and redox signaling

A Bindoli, JM Fukuto, HJ Forman - Antioxidants & redox signaling, 2008 - liebertpub.com
The oxidation chemistry of thiols and disulfides of biologic relevance is described. The
review focuses on the interaction and kinetics of hydrogen peroxide with low-molecular …

Oxidant—antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options

A Nadeem, A Masood… - Therapeutic advances in …, 2008 - journals.sagepub.com
Prevalence of asthma has increased considerably in recent decades throughout the world
especially in developed countries. Airway inflammation is thought to be prime cause for …

A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity

K Ando, S Hirao, Y Kabe, Y Ogura, I Sato… - Nucleic acids …, 2008 - academic.oup.com
Abstract APE1/Ref-1 is thought to be a multifunctional protein involved in reduction–
oxidation (redox) regulation and base excision DNA repair, and is required for early …

Cu (I)–Glutathione complex: A potential source of superoxide radicals generation

H Speisky, M Gómez, C Carrasco-Pozo… - Bioorganic & medicinal …, 2008 - Elsevier
Cu2+ ions and GSH molecules interact swiftly to form the complex Cu (I)–glutathione. We
investigated the potential capacity of such complex to reduce molecular oxygen. The …

The biochemistry of drug metabolism–an introduction: part 4. reactions of conjugation and their enzymes

B Testa, SD Kraemer - Chemistry & biodiversity, 2008 - Wiley Online Library
This review continues a general presentation of the metabolism of drugs and other
xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is …

Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of α-lipoic acid

K Manda, M Ueno, K Anzai - Behavioural brain research, 2008 - Elsevier
Exposure to high-energy particle radiation (HZE) may cause oxidative stress and cognitive
impairment in the same manner that seen in aged mice. This phenomenon has raised the …

Toxicological effects of methylmercury on walleye (Sander vitreus) and perch (Perca flavescens) from lakes of the boreal forest

C Larose, R Canuel, M Lucotte, RT Di Giulio - … Biochemistry and Physiology …, 2008 - Elsevier
Biochemical and physiological responses of walleye (Sander vitreus) and perch (Perca
flavescens) were studied in four Canadian boreal forest lakes representing a mercury (Hg) …

Oxidant–antioxidant imbalance as a potential contributor to the progression of human pulmonary fibrosis

VL Kinnula, M Myllärniemi - Antioxidants & redox signaling, 2008 - liebertpub.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia. IPF
is a disease with poor prognosis and an aggressive nature, and poses major challenges to …

Metabolic rate and reactive oxygen species production in different genotypes of GH-transgenic zebrafish

CE Rosa, MA Figueiredo, CFC Lanes… - … and Physiology Part B …, 2008 - Elsevier
Growth hormone overexpression increases growth and consequently increases the
metabolic rate in fishes. Therefore, the objective of this study was to evaluate the effects of …