For many years primary aldosteronism was considered a relatively benign form of
hypertension. This assumption reflects the primacy accorded to elevated levels of …

Background Primary aldosteronism is much more common than previously held; it implies
an excessive organ damage to the heart, vessels and kidney, which translates into an …

Objective: Our objective was to develop clinical practice guidelines for the diagnosis and
treatment of patients with primary aldosteronism. Participants: The Task Force comprised a …

Background Results of several studies published since 1999 suggest that primary
hyperaldosteronism (also known as Conn's syndrome) affects more than 10% of people with …

this context, a contribution of the adipose-tissue RAS, in addition to the classic RAS, is
discussed in the development of insulin resistance and hypertension. 26, 28 Studies …

Background Aldosterone has been shown to substantially contribute to the accumulation of
different types of collagen fibers and growth factors in the arterial wall, which increase wall …

There is increasing evidence indicating the roles of aldosterone and mineralocorticoid
receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone …

Experimental data indicate that the cardiorenal effects of aldosterone excess are dependent
on concomitant high dietary salt intake. Such an interaction of endogenous aldosterone and …

Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure
homeostasis by acting on the distal nephron. Accumulating evidence suggests that …

MicroRNAs (miRNAs) are endogenous small noncoding RNAs that decrease the expression
levels of specific genes by translational repression, sequestration, and degradation of their …