Emerging data indicate that progesterone has multiple non-reproductive functions in the
central nervous system to regulate cognition, mood, inflammation, mitochondrial function …

Progesterone, although still widely considered primarily a sex hormone, is an important
agent affecting many central nervous system functions. This review assesses recent …

Background Severe traumatic brain injury (TBI) has been increasing with greater incidence
of injuries from traffic or sporting accidents. Although there are a number of animal models of …

Traumatic brain injury (TBI) represents a major health care problem and a significant
socioeconomic challenge worldwide. In the United States alone, approximately 1.5 million …

In this article, we review published preclinical and epidemiologic studies that examine
progesterone's role in the central nervous system. Its effects on the reproductive and …

Anesthesiologists are frequently confronted with patients who are at risk for neurological
complications due to perioperative stroke or prior traumatic brain injury. In this review, we …

This study investigated whether progesterone administration modulates toll-like receptors
(TLRs) and the nuclear factor-kappa B (NF-κB) signaling pathway in the injured rat brain …

Estradiol and progesterone are two steroid hormones that target a variety of organ systems,
including the heart, the bone and the brain. With respect to the latter, a large volume of basic …

BACKGROUND: Traumatic brain injury (TBI) can induce a persistent inflammatory response,
histopathological changes, and apoptosis in the gut. Progesterone given after TBI has been …

Our laboratory has shown in numerous experiments that the neurosteroids progesterone
(PROG) and allopregnanolone (ALLO) improve molecular and functional outcomes after …