Active targeting schemes for nanoparticle systems in cancer therapeutics

JD Byrne, T Betancourt, L Brannon-Peppas - Advanced drug delivery …, 2008 - Elsevier
The objective of this review is to outline current major cancer targets for nanoparticle
systems and give insight into the direction of the field. The major targeting strategies that …

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt (IV) prodrug-PLGA–PEG nanoparticles

S Dhar, FX Gu, R Langer… - Proceedings of the …, 2008 - National Acad Sciences
Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and
acquired resistance limit its application in many types of cancer including prostate. We report …

Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA)

SS Chandran, S R. Banerjee, R C. Mease… - Cancer biology & …, 2008 - Taylor & Francis
Polymeric nanoparticles represent a form of targeted therapy due to their ability to passively
accumulate within the tumor interstitium via the enhanced permeability and retention (EPR) …

Prostate-specific membrane antigen expression in regeneration and repair

IO Gordon, MS Tretiakova, AE Noffsinger, J Hart… - Modern …, 2008 - nature.com
Prostate-specific membrane antigen is a type II transmembrane glycoprotein, expressed in
benign and neoplastic prostatic tissue as well as endothelial cells of neovasculature from a …

Cell‐Surface labeling and internalization by a fluorescent inhibitor of prostate‐specific membrane antigen

T Liu, LY Wu, M Kazak, CE Berkman - The Prostate, 2008 - Wiley Online Library
BACKROUND Prostate‐specific membrane antigen (PSMA) remains an attractive target for
imaging and therapeutic applications for prostate cancer. Recent efforts have been made to …

Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis

V Yao, A Parwani, C Maier, WDW Heston, DJ Bacich - Cancer research, 2008 - AACR
Increased expression of PSMA, a differentiation antigen with folate hydrolase activity, is an
independent marker of prostate cancer progression. Mice expressing moderate levels of …

Identification of gene interactions associated with disease from gene expression data using synergy networks

J Watkinson, X Wang, T Zheng, D Anastassiou - BMC systems biology, 2008 - Springer
Background Analysis of microarray data has been used for the inference of gene-gene
interactions. If, however, the aim is the discovery of disease-related biological mechanisms …

Expression of prostate-specific membrane antigen in renal cortical tumors

HA Al-Ahmadie, S Olgac, PD Gregor, SK Tickoo… - Modern …, 2008 - nature.com
Prostate-specific membrane antigen is a type II membrane glycoprotein that is expressed in
benign and neoplastic prostatic tissue and has been recently shown to be also expressed in …

Monoclonal antibody therapy for prostate cancer

A Jakobovits - Therapeutic Antibodies, 2008 - Springer
Early detection of prostate cancer (PCa) and advances in hormonal and chemotherapy
treatments have provided great clinical benefits to patients with early stages of the disease …

Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma

P Mhawech-Fauceglia, DJ Smiraglia, W Bshara… - … biomarkers & prevention, 2008 - AACR
The aim of this study was to determine the role of prostate-specific membrane antigen
(PSMA) as a prognostic marker in endometrial adenocarcinoma (EAC) and to explore …