The business of defending the body against invading microorganisms relies heavily on the
action of monocytes/macrophages and granulocytes (also called neutrophils). These …

Context: The enzyme 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2) exerts a local
antiestrogenic effect by metabolizing biologically active estradiol to inactive estrone in …

MAPK signaling is required for retinoic acid (RA)-triggered G 0 cell cycle arrest and cell
differentiation, but the mechanism is not well defined. In this study, RA is found to cause …

Retinoic acid (RA) is known to regulate cell growth and differentiation. In HL-60 human
myeloblastic leukemia cells, it causes mitogen-activated protein kinase (MAPK) signaling …

Background and purpose: All‐trans retinoic acid (ATRA) induces complete remission in a
majority of acute promyelocytic leukaemia patients, but resistance of leukaemic cells to …

Even though RA is involved in differentiation and apoptosis of normal and cancer cells,
being sometimes used as adjuvant in chemotherapy, its mechanisms of action involve …

Estrogen receptors are historically perceived as nuclear ligand activated transcription
factors. An estrogen receptor has now been found localized to the plasma membrane of …

The differentiation of promyelocytic leukemic cells into mature cells is the major strategy for
drug-based treatment of leukemia. Higher efficient methods to differentiate promyelocytic …

Interferon-α (IFN-α) has been used in the treatment of several cancers, including chronic
myeloid leukemia. Artemisinin, a sesquiterpene lactone endoperoxide that exists in several …

Lithocholic acid (LCA) acetate induced the differentiation of human leukemia cells.
Treatment with a combination of LCA acetate and cotylenin A, an inducer of the …