Increasing evidence points to insulin resistance as a primary etiologic factor in the
development of nonischemic heart failure (HF). The myocardium normally responds to injury …

Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-
bromopyrimidin-2-yloxy) ethoxy)-pyrimidin-4-yl]-N′-propylaminosulfonamide], is a new …

Background: Cardiac inflammation and generation of oxidative stress are known to
contribute to doxorubicin (Dox)‐induced cardiomyopathy. Toll‐like receptors (TLRs) are a …

Tetracycline is a powerful tool for controlling the expression of specific transgenes (TGs) in
various tissues, including heart. In these mouse systems, TG expression is …

Endothelin-1 (ET-1) exhibits potent proinflammatory and profibrotic properties. Moreover,
inflammation is a potent stimulus for inducible NO synthase (iNOS), which has been shown …

Endothelin (ET)-1 regulates the contractility and growth of the heart by binding G protein-
coupled receptors of the ET type A receptor (ETA)/ET type B (ETB) receptor family. ETA, the …

Clinical and experimental evidence has demonstrated the development of cardiac
dysfunction and heart failure in patients with advanced viral or bacterial infection, severe …

The main cause of morbidity and mortality in pulmonary arterial hypertension (PAH) is not
injury to the lung, but rather progressive right ventricular (RV) dysfunction. Although the …

With increasing prevalence and high mortality, heart failure (HF) emerges as a major health
problem. The heart often undergoes myocardial hypertrophy in response to increased load …

Calcified aortic valve disease represents a spectrum of disease spanning from mild aortic
valve sclerosis to severe aortic valve stenosis (AS), being an actively regulated disease …