Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

A search for general regulators of cancer metastasis has yielded a set of microRNAs for
which expression is specifically lost as human breast cancer cells develop metastatic …

EZH2 is the catalytic subunit of Polycomb repressive complex 2 (PRC2), which is a highly
conserved histone methyltransferase that targets lysine-27 of histone H3. This methylated …

Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts,
cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake …

Post-translational modification of histone N-tails affects eukaryotic gene activity. In
Arabidopsis, the histone modification level correlates with gene activation and repression in …

Several aspects of epigenetics are strongly linked to non-coding RNAs, especially small
RNAs that can direct the cytosine methylation and histone modifications that are implicated …

Histone modifications play critical roles in the epigenetic regulation of gene expression and
in the maintenance of genome integrity. Acetylation and methylation of histone H3 are …

Methylation of lysine 27 on histone H3 (H3K27) by the EZH2 complex is an epigenetic mark
that mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with …

Purpose: Epigenetic modifications of histone have crucial roles in the control of gene activity,
nuclear architecture, and genomic stability. In this respect, they may contribute to the …