Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications

ED Burg, CV Remillard… - British journal of …, 2008 - Wiley Online Library
Maintaining the proper balance between cell apoptosis and proliferation is required for
normal tissue homeostasis; when this balance is disrupted, disease such as pulmonary …

Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells

J Qiu, HQ Gao, Y Liang, H Yu, RH Zhou - Biochimica et Biophysica Acta …, 2008 - Elsevier
Although digitalis has been used in clinical treatment extensively, the precise mechanism of
its toxic actions on cardiovascular system remained unclear, it would be of interest to study …

[Na+]i/[K+]i-independent death of ouabain-treated renal epithelial cells is not mediated by Na+,K+-ATPase internalization and de novo gene expression

OA Akimova, P Hamet, SN Orlov - Pflügers Archiv-European Journal of …, 2008 - Springer
The cytotoxic effect of long-term exposure of renal epithelial cells to ouabain and other
cardiotonic steroids (CTS) is mediated by the interaction of these compounds with Na+, K+ …

The death of ouabain-treated renal epithelial cells: evidence against anoikis occurrence

OA Akimova, M Poirier, SV Kotelevtsev, P Hamet… - Apoptosis, 2008 - Springer
The mechanisms of cell death signaling triggered by cardiotonic steroids are poorly
understood. Based on massive detachment of ouabain-treated Madin-Darby canine kidney …

Altered Phosphorylation of RRXS*/T* Motif in Ouabain-Treated Renal Epithelial Cells is not Mediated by Inversion of the [Na+]i/[K+]i Ratio

OA Akimova, OD Lopina, J Tremblay, P Hamet… - Cellular Physiology and …, 2008 - karger.com
Recently, we reported that the death of ouabain-treated C7-MDCK cells resembling principal
cells from collecting ducts of the Madin-Darby canine kidney (MDCK) is caused by ouabain …