Endometriosis remains an enigmatic disorder in that the cause, the natural history, and the
precise mechanisms by which it causes pain are not completely understood. The pain …

Since 1996, when the authors assembled the existing body of knowledge about lower
urinary tract disease in cats, the understanding of the biological behavior and pathologic …

OBJECTIVES: The urinary proteome is a potential easily accessible source of biomarkers for
inflammatory bladder diseases, including interstitial cystitis. In the present study, we …

Background Interstitial cystitis (IC), a chronic bladder disease with an increasing incidence,
is diagnosed using subjective symptoms in combination with cystoscopic and histological …

Hyperexcitability of C-fiber bladder afferent pathways has been proposed to contribute to
urinary frequency and bladder pain in chronic bladder inflammation including interstitial …

Interstitial cystitis/painful bladder syndrome (IC/PBS) is a major challenge to treat. We
studied the effect of targeted and localized expression of enkephalin in afferent nerves that …

Mast cells have been shown to play a role in development and persistence of various
inflammatory bladder disorders. Mast cell-derived tryptase specifically activates protease …

To describe the pathophysiology, diagnosis and controversies surrounding the diagnosis
and pharmacological treatments of painful bladder syndrome/interstitial cystitis (PBS/IC) in …

Interstitial cystitis (IC)/painful bladder syndrome (PBS) is a painful debilitating chronic
visceral pain disorder of unknown etiology that affects an estimated 1 million people in the …

The apparently simple repertoire of bladder function comprising the storage and periodic
elimination of urine is under the complex regulatory control of a neural system that involves …