This review emphasizes the pathologic features of psoriatic lesions, recent genetic studies of
psoriasis, and immunologic factors in the disease. The evolution of a psoriatic lesion entails …

Modern tools for genetic analysis are producing a large impact on our understanding of
autoimmunity. More than 30 genome-wide association studies (GWAS) have been …

We performed a genome-wide association study (GWAS) of systemic lupus erythematosus
(SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using …

To date, most genome-wide association studies (GWAS) and studies of fine-scale
population structure have been conducted primarily on Europeans. Han Chinese, the largest …

Population stratification is a potential problem for genome-wide association studies (GWAS),
confounding results and causing spurious associations. Hence, understanding how allele …

Psoriasis is a common inflammatory skin disease characterized by thickened scaly red
plaques. Previously we have performed a genome-wide association study (GWAS) on …

Recent advances have enabled a comprehensive understanding of the genetic architecture
of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The …

Psoriasis is an immune-mediated skin disorder, which is inherited as a complex trait.
Genome-wide linkage and association studies have identified a major disease susceptibility …

TNF-α antagonists have been shown to be very effective for the treatment of various
rheumatic and nonrheumatic diseases, including psoriasis, and for off-label use in other …

Psoriasis is a chronic inflammatory skin disease characterised by elevated red scaly
plaques on specific body sites. Histologically, the plaques are defined by epidermal …