Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Maternal age and chromosomally abnormal pregnancies: what we... : Current Opinion in
Pediatrics Maternal age and chromosomally abnormal pregnancies: what we know and what we …

BubR1 is an essential mitotic checkpoint protein with multiple functional domains. It has
been implicated in mitotic checkpoint control, as an active kinase at unattached …

Aneuploidy is defined as numerical abnormalities of chromosomes and is frequently (> 90%)
present in solid tumors. In general, tumor cells become increasingly aneuploid with tumor …

Two critical stages of mammalian oocyte regulation are prophase I arrest, which is important
for sustaining the oocyte pool, and the progression through meiosis I (MI) to produce …

The role of various p73 isoforms in tumorigenesis has been controversial. However, as we
have recently shown, the generation of TAp73-deficient (TAp73−/−) mice reveals that TAp73 …

Down syndrome caused by meiotic nondisjunction of chromosome 21 in humans, is well
known to be associated with advanced maternal age, but success in identifying and …

Genomic instability is a hallmark of human cancers. Spindle assembly checkpoint (SAC) is a
critical cellular mechanism that prevents chromosome missegregation and therefore …

Advanced maternal age is unequivocally associated with increased aneuploidy in human
eggs and infertility, but the molecular basis for this phenomenon is unknown. An age …