The human leukocyte antigen (HLA) super-locus is a genomic region in the chromosomal
position 6p21 that encodes the six classical transplantation HLA genes and at least 132 …

Variation in gene expression is an important mechanism underlying susceptibility to
complex disease. The simultaneous genome-wide assay of gene expression and genetic …

Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci
have been the prototypical candidates for genetic susceptibility to infectious disease …

In 1958, just a little more than 50 years ago, an alloantigen present on human leucocytes
was detected, which was to become the 'first'human leucocyte antigen (HLA); HLA‐A2 …

Operons (clusters of co-regulated genes with related functions) are common features of
bacterial genomes. More recently, functional gene clustering has been reported in …

The swine major histocompatibility complex (MHC) or swine leukocyte antigen (SLA)
complex is one of the most gene-dense regions in the swine genome. It consists of three …

Conservation genetics focuses on understanding the role and requirement of genetic
variation for population persistence. However, considerable debate now surrounds the role …

Polymorphic genes of the major histocompatibility complex (MHC) are regarded as essential
genes for individual fitness under conditions of natural and sexual selection. To test this …

Although the introduction of genome-wide association studies (GWAS) have greatly
increased the number of genes associated with common diseases, only a small proportion …

The MHC class II association with MS is not as straightforward as previously thought. A
complete understanding of the epistatic interactions and epigenetic features of this region …