This book is intended to provide a general introduction to this exciting field of plant cell and
tissue culture as tool in biotechnology, without overly dwelling on detailed descriptions of all …

Dysregulation of the ubiquitin‐proteasome pathway plays an essential role in tumor growth
and development. Shikonin, a natural naphthoquinone isolated from the traditional Chinese …

We previously reported that shikonin could circumvent drug resistance mediated by P-gp,
Bcl-2 and Bcl-xL, by induction of necroptosis. Here, we show that the naturally-occurring …

Background Shikonin derivatives have cytotoxic and antitumor effects. This study aims to
investigate the antitumor effects of acetylshikonin isolated from a Chinese medicinal herb …

Steroid sulfatase (STS) has an important role in regulating the biosynthesis of estrogen
within breast tumors. We aimed to investigate whether shikonin, an ingredient of …

A series of shikonin analogues with side chain variants have been synthesized and
evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro …

A simple, precise, and rapid high‐performance thin‐layer chromatographic (HPTLC) method
for the simultaneous quantification of pharmacologically important naphthoquinone shikonin …

AIM: To investigate the inhibitory effect of acetylshikonin on human gastric carcinoma cell
line SGC-7901 and its mechanism. METHODS: MTT assay was used to assess the inhibitory …

MATERIALS AND METHODS Animals and Treatment Regimens Sixty eight-weekold female
NZB/W F1/J mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA) and …

The birth of drug discovery is closely connected to the study of plant natural products and
was shaped by two seminal events, the isolation of morphine 1 from opium by the …