The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

Psychiatric comorbidities are common among patients with schizophrenia. Substance abuse
comorbidity predominates. Anxiety and depressive symptoms are also very common …

Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

The onset of adolescence, and more specifically the advent of pubertal maturation,
represents a key developmental window for understanding the emergence of …

The long-term consequences of early environmental experiences for development have
been explored extensively in animal models to better understand the mechanisms mediating …

The association between cannabis use and psychosis has long been recognized. Recent
advances in knowledge about cannabinoid receptor function have renewed interest in this …

Background: The adverse health effects of cannabis are a source of contention in debates
about policies towards the drug. Methods: This paper provides a review of epidemiological …

The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex
involving both heritable and nonheritable factors. The absence of consistently replicated …

Objective: The authors sought to determine whether prenatal exposure to infection and a
positive family history of psychotic disorders interact synergistically to increase the risk of …

Schizophrenia is a severe disorder that disrupts the function of multiple brain systems,
resulting in impaired social and occupational functioning. The etiology and pathogenesis of …