Neuroimaging studies have gained increasing importance in validating neurobiological
network hypotheses for anxiety disorders. Functional imaging procedures and radioligand …

Data from studies with humans have suggested that abnormalities of midbrain structures,
including the periaqueductal gray matter (PAG), could be involved in the neurobiology of …

To investigate whether prefrontal function during a cognitive task reflects the severity of
panic disorder, the prefrontal function during a word fluency task in 109 panic disorder …

Other chapters in this volume provide a more detailed account of the clinical factors that
weigh in favor of specific definitions of diagnoses, as well as their grouping within broader …

Alterations of regional brain activity in the prefrontal cortex and in limbic areas have been
reported in humans with anxiety disorders. This animal study reports the results of brain …

Lactate uses an unknown mechanism to induce panic attacks in people and panic-like
symptoms in rodents. We tested whether intraperitoneal (IP) lactate injections act …

神经影像技术的快速发展及广泛应用为神经症的发病机制研究提供了有效的手段, 研究发现,
惊恐性障碍患者不仅区域性脑血流(rCBF) 及脑葡萄糖代谢率出现异常, 某些脑结构的容积也有 …

In this chapter, we review preclinical and clinical data relevant to normal and pathological
anxiety states. We begin with a brief summary of paradigms of fear learning. We then relate …

Anxiety and fear are normal human emotional states that serve to alert an individual to
potential threat in the environment. However, individuals with anxiety disorders persistently …

Panic disorder (PD) is a quite common condition (lifetime prevalence is 4%) that significantly
affects people's quality of life. An important theory concerning the nature and cause of PD is …