The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is
dysregulated in various cancers, and its upregulation strongly correlates with an invasive …

A primary failsafe program against unrestrained proliferation and oncogenesis is provided
by the p53 tumor suppressor protein, inactivation of which is considered as a hallmark of …

Identification of bona fide tumor suppressors is often challenging because of the large
number of genetic alterations present in most human cancers. To evaluate candidate genes …

The histone H3 demethylase Not dead yet-1 (Ndy1/KDM2B) is a physiological inhibitor of
senescence. Here, we show that Ndy1 is down-regulated during senescence in mouse …

Tumor response in the B6C3F1 mouse, F344 rat, and other animal models following
exposure to various compounds provides evidence that people exposed to these or similar …

B-lymphoma Moloney murine leukaemia virus insertion region-1 (BMI1) is a member of the
polycomb group of transcription repressors, which functions in stem cell maintenance and …

Bmi1 is a polycomb group proto-oncogene that has been implicated in multiple tumor types.
However, its role in hepatocellular carcinoma (HCC) development has not been well …

PURPOSE: This study was conducted to determine the expression of Bmi-1 and podoplanin
in healthy oral mucosa and in untreated, tumor tissues samples of patients with squamous …

The progression and metastasis of solid tumors, including head and neck squamous cell
carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer …

Target molecules for a highly sensitive and specific diagnosis of breast cancer in its early
clinical stages have not yet been identified. Here, we show the first evidence for diagnostic …