Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor β-mediated, not by retinoic acid receptor α-mediated, phosphatidylinositol 3-kinase …

B Zheng, M Han, M Bernier, X Zhang, F Meng… - Journal of Biological …, 2009 - ASBMB
Proliferation inhibition of vascular smooth muscle cells (VSMCs) is governed by the activity
of a transcription factor network. Krüppel-like factor 4 (Klf4), retinoic acid receptor (RARα) …

Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells

F Nagl, K Schönhofer, B Seidler… - … of Physiology-Cell …, 2009 - journals.physiology.org
Neuronal nitric oxide synthase (nNOS)-derived nitric oxide (NO) acts as a neurotransmitter
and intracellular signaling molecule in the central and peripheral nervous system. NO …

A unique cytoplasmic localization of retinoic acid receptor-γ and its regulations

YH Han, H Zhou, JH Kim, T Yan, KH Lee, H Wu… - Journal of Biological …, 2009 - ASBMB
Recent evidence suggests that extranuclear action of retinoid receptors is involved in
mediating the pleiotropic effects of retinoids. However, whether they reside in the cytoplasm …

Retinoic acid activates monoamine oxidase B promoter in human neuronal cells

JB Wu, K Chen, XM Ou, JC Shih - Journal of Biological Chemistry, 2009 - ASBMB
Monoamine oxidase (MAO) B deaminates a number of biogenic and dietary amines and
plays an important role in many biological processes. Among hormonal regulations of MAO …

Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells

J Smith, RP Bunaciu, G Reiterer, D Coder… - Experimental cell …, 2009 - Elsevier
All trans-retinoic acid (RA) is a standard therapeutic agent used in differentiation induction
therapy treatment of acute promyelocytic leukemia (APL). RA and its metabolites use a …

c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 …

M Shen, A Yen - Journal of Biological Chemistry, 2009 - ASBMB
Retinoic acid (RA) causes HL-60 human myeloblastic leukemia cell myeloid differentiation
that is dependent on MAPK signaling. The process is propelled by c-Cbl, which binds the …

Nicotinamide cooperates with retinoic acid and 1, 25-dihydroxyvitamin D3 to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells

M Shen, A Yen - Oncology, 2009 - karger.com
Nicotinamide, the amide derivative of vitamin B 3, cooperates with retinoic acid (RA), a form
of vitamin A, and 1, 25-dihydroxyvitamin D 3 (D3), to regulate cell differentiation and …

Targeting V1A‐vasopressin receptors with [Arg6, D‐Trp7,9, NmePhe8]‐substance P (6‐11) identifies a strategy to develop novel anti‐cancer therapies

AC MacKinnon, U Tufail‐Hanif… - British journal of …, 2009 - Wiley Online Library
Background and purpose: The anti‐cancer agent [Arg6, D‐Trp7, 9, NmePhe8]‐substance P
(6‐11)(SP‐G) modulates gastrin releasing peptide (GRP) and arginine vasopressin …

[PDF][PDF] MAPK 信号通路与大肠癌

季语祝, 综述, 王芳 - 肿瘤防治研究, 2009 - zlfzyj.com
QJ6 有如下几种亚型! 经典型%((, $(,%(+ & $ 新发现型% 1 ()(2 (3& 及非经典型% 4 (5&'QJ6
亚型的激活是导致各种细胞反应发生的级联反应中最早期的事件之;**+'QJ6 的活性有利于T> Q …

Gonadotropin-releasing hormone and its receptor as a therapeutic concept in the progression of epithelial ovarian cancer

KY Kim, KC Choi - Journal of Embryo Transfer, 2009 - koreascience.kr
Ovarian cancer is a significant cause of cancer-related death in women, but the main
biological causes remain open questions. Hormonal factors have been considered to be an …