Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

More than 70 years after its initial report, caloric restriction stands strong as the most
consistent non-pharmacological intervention increasing lifespan and protecting against …

Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in
multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an …

Cells undergoing developmental processes are characterized by persistent non-genetic
alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA …

The molecular mechanisms that cause organismal aging are a topic of intense scrutiny and
debate. Dietary restriction extends the life span of many organisms, including yeast, and …

The Sir2 chromatin regulatory factor links maintenance of genomic stability to life span
extension in yeast. The mammalian Sir2 family member SIRT6 has been proposed to have …

Eukaryotic cells from neurons and epithelial cells to unicellular fungi frequently rely on
cellular appendages such as axons, dendritic spines, cilia, and buds for their biology. The …

The replicative life span (RLS) of Saccharomyces cerevisiae has been established as a
model for the genetic regulation of longevity despite the inherent difficulty of the RLS assay …

The sirtuins are a protein family named after the first identified member, S. cerevisiae Sir2p.
Sirtuins are protein deacetylases whose activity is dependent on NAD+ as a cosubstrate …

Recent studies have emphasized the importance of SIRT1, a mammalian homolog of Sir2
longevity factor, in the regulation of metabolism, cellular survival, and organismal lifespan …