Identification of drug metabolites by liquid chromatography/mass spectrometry (LC/MS)
involves metabolite detection in biological matrixes and structural characterization based on …

Biotransformation of chemically stable compounds to reactive metabolites which can bind
covalently to macromolecules, such as proteins and DNA, is considered as an undesirable …

Prediction of idiosyncratic drug-induced liver injury (DILI) is difficult, and the underlying
mechanisms are not fully understood. However, many drugs causing DILI are considered to …

Oral disintegrating film containing prochlorperazine, a dopamine D2 receptor antagonist
with anti-emetic property, was newly developed using microcrystalline cellulose, polyethlene …

A combination of high performance liquid chromatography (HPLC) and mass spectrometry
(LC/MS) has proven its status as the most powerful analytical tool for screening and …

In an increasing number of cases, a deeper understanding of the biochemical basis for
idiosyncratic adverse drug reactions (IADRs) has aided to replace a vague perception of a …

The first edition of this now classic work helped to establish mass spectrometry as the
premier tool for drug metabolism studies. Completely rewritten from start to finish, Using …

Integrating physicochemical, drug metabolism, pharmacokinetics, ADME, and toxicity assays
into drug discovery in order to reduce the attrition rates in clinical development is reviewed …

Reactive metabolites are believed to be one of the main reasons for unexpected drug‐
induced toxicity issues, by forming covalent adducts with cell proteins or DNA. Due to their …

The high attrition rate in drug development and the deteriorated drug ability as a result of the
shifted chemical space of new therapeutic target for unmet medical needs have posed …