Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data
T Heimbach, SB Lakshminarayana, W Hu, H He - The AAPS journal, 2009 - Springer
Accurate predictions of human pharmacokinetic and pharmacodynamic (PK/PD) profiles are
critical in early drug development, as safe, efficacious, and “developable” dosing regimens …
critical in early drug development, as safe, efficacious, and “developable” dosing regimens …
How to integrate in vitro PK/PD information for toxicity prediction
FY Bois - 7. World congress on alternatives and animal use in …, 2009 - ineris.hal.science
Predicting drugs' in vivo effects from in vitro testing requires modelling processes that are not
reproduced by in vitro systems. The most obvious difference between the two situations is …
reproduced by in vitro systems. The most obvious difference between the two situations is …
[引用][C] Predicting Interindividual Variability of Metabolic Drug–Drug Interactions: Identifying the Causes and Accounting for Them Using a Systems Approach
A Rostami‐Hodjegan - … and Development: The Good and the …, 2009 - Wiley Online Library
Predicting Interindividual Variability of Metabolic Drugâ•fiDrug Interactions: Identifying the
Causes and Accounting for The Page 1 18 549 PREDICTING INTERINDIVIDUAL VARIABILITY …
Causes and Accounting for The Page 1 18 549 PREDICTING INTERINDIVIDUAL VARIABILITY …