While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

The traditional view of p53 activation includes three steps—p53 stabilization, DNA binding,
and transcriptional activation. However, recent studies indicate that each step of p53 …

Summary Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal
development and has been linked to several high-risk cancers. Here, we report that LSD1 is …

Histone methylation and DNA methylation cooperatively regulate chromatin structure and
gene activity. How these two systems coordinate with each other remains unclear. Here we …

The p53 protein is modified by as many as 50 individual posttranslational modifications.
Many of these occur in response to genotoxic or nongenotoxic stresses and show …

Jmjd3, a JmjC family histone demethylase, is induced by the transcription factor NF‐kB in
response to microbial stimuli. Jmjd3 erases H3K27me3, a histone mark associated with …

Histone modifying enzymes catalyze the addition or removal of an array of covalent
modifications in histone and non-histone proteins. Within the context of chromatin, these …

Methylation of Lys residues on histone proteins is a well known and extensively
characterized epigenetic mark. The recent discovery of lysine-specific demethylase 1 …

Reversible methylation of histone tails serves as either a positive signal recognized by
transcriptional assemblies or a negative signal that result in repression,,,. Invading viral …

Post-translational modification of chromatin is emerging as an increasingly important
regulator of chromosomal processes. In particular, histone lysine and arginine methylation …