Despite extensive research, the current theories on serotonergic dysfunctions and cortisol
hypersecretion do not provide sufficient explanations for the nature of depression. Rational …

Tryptophan is an essential amino acid that can be metabolised through different pathways, a
major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2 …

Picolinic Acid is an endogenous metabolite of L-tryptophan (TRP) that has been reported to
possess a wide range of neuroprotective, immunological, and anti-proliferative affects within …

Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and
more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the …

Depression and fatigue are frequent side effects of interferon-α (IFN-α) treatment, and there
is compelling evidence that the inflammatory response system (including interleukin-6, IL-6) …

The kynurenine pathway constitutes the main route of tryptophan degradation and
generates the production of several neuroactive compounds; quinolinic acid is an excitotoxic …

Recent studies have demonstrated that kynurenic acid (KYNA), a compound produced
endogenously by the interferon-γ-induced degradation of tryptophan by indoleamine 2, 3 …

The metabolism of tryptophan mostly proceeds through the kynurenine pathway. The
biochemical reaction includes both an agonist (quinolinic acid) at the N-methyl-d-aspartate …

Aim The pathophysiology of delirium remains elusive though neurotransmitters and their
precursor large neutral amino acids (LNAAs) may play a role. This pilot study investigated …

An inflammatory pathogenesis has been postulated for schizophrenia and major depression
(MD). In schizophrenia and depression, opposing patterns oftype-1 vs type-2 immune …