Mental disorders are as prevalent among college students as same-aged non-students, and
these disorders appear to be increasing in number and severity. The purpose of this report is …

OBJECTIVE To systematically assess the evidence for an association between sexual
abuse and a lifetime diagnosis of psychiatric disorders. PATIENTS AND METHODS We …

People have engaged in self-injury—defined as direct and deliberate bodily harm in the
absence of suicidal intent—for thousands of years; however, systematic research on this …

Resilience has been conceptualized as a dynamic developmental process encompassing
the attainment of positive adaptation within the context of significant threat, severe adversity …

Spanning functions from the simplest reflex arc to complex cognitive processes, neural
circuits have diverse functional roles. In the cerebral cortex, functional domains such as …

This review begins with a brief historical overview of attempts in the first half of the 20th
century to discern brain systems that underlie emotion and emotional behavior. These early …

Evidence of marked variability in response among people exposed to the same
environmental risk implies that individual differences in genetic susceptibility might be at …

Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …

BackgroundChildhood adversity (CA) is associated with adult mental disorders, but the
mechanisms underlying this association remain inadequately understood. Stress …