[HTML][HTML] Nonresolving inflammation
C Nathan, A Ding - Cell, 2010 - cell.com
Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an
inherent risk because inflammation can damage tissue and necrosis can provoke …
inherent risk because inflammation can damage tissue and necrosis can provoke …
Macrophages, inflammation, and insulin resistance
JM Olefsky, CK Glass - Annual review of physiology, 2010 - annualreviews.org
Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …
The transcriptional network for mesenchymal transformation of brain tumours
The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …
pathological cellular states remains a central challenge in systems biology. A mesenchymal …
Computational solutions to large-scale data management and analysis
Today we can generate hundreds of gigabases of DNA and RNA sequencing data in a week
for less than US $5,000. The astonishing rate of data generation by these low-cost, high …
for less than US $5,000. The astonishing rate of data generation by these low-cost, high …
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
The recent success of genome-wide association studies (GWAS) is now followed by the
challenge to determine how the reported susceptibility variants mediate complex traits and …
challenge to determine how the reported susceptibility variants mediate complex traits and …
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
Gene expression measurements are influenced by a wide range of factors, such as the state
of the cell, experimental conditions and variants in the sequence of regulatory regions. To …
of the cell, experimental conditions and variants in the sequence of regulatory regions. To …
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans
JA Timmons, S Knudsen, T Rankinen… - Journal of applied …, 2010 - journals.physiology.org
A low maximal oxygen consumption (V̇o2max) is a strong risk factor for premature
mortality. Supervised endurance exercise training increases V̇o2max with a very wide …
mortality. Supervised endurance exercise training increases V̇o2max with a very wide …
Weighted gene coexpression network analysis: state of the art
Weighted gene coexpression network analysis (WGCNA) has been applied to many
important studies since its introduction in 2005. WGCNA can be used as a data exploratory …
important studies since its introduction in 2005. WGCNA can be used as a data exploratory …
An official American Thoracic Society Workshop report: obesity and asthma
Rationale: The developed world is currently facing an epidemic of obesity. With the
increased prevalence of obesity has come the recognition that obesity is a risk factor for …
increased prevalence of obesity has come the recognition that obesity is a risk factor for …
Systems vaccinology
Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …