Crystallization of synthetic haemozoin (β-haematin) nucleated at the surface of lipid particles

AN Hoang, KK Ncokazi, KA de Villiers, DW Wright… - Dalton …, 2010 - pubs.rsc.org
The mechanism of formation of haemozoin, a detoxification by-product of several blood-
feeding organisms including malaria parasites, has been a subject of debate; however …

The Neutral Lipid Composition Present in the Digestive Vacuole of Plasmodium falciparum Concentrates Heme and Mediates β-Hematin Formation with an …

AN Hoang, RD Sandlin, A Omar, TJ Egan… - Biochemistry, 2010 - ACS Publications
In eukaryotic cells, neutral lipids serve as major energy storage molecules; however, in
Plasmodium falciparum, a parasite responsible for causing malaria in humans, neutral lipids …

Lipophilic mediated assays for β-hematin inhibitors

MD Carter, VV Phelan, RD Sandlin… - … chemistry & high …, 2010 - ingentaconnect.com
The growing drug resistance of Plasmodia spp. to current antimalarial agents in the quinine
and artemisinin families further asserts the need for novel drug classes to combat malaria …

Self-assembled monolayers as templates for heme crystallization

X Wang, E Ingall, B Lai, AG Stack - Crystal growth & design, 2010 - ACS Publications
Homogeneous self-assembled monolayers (SAMs) of alkanethiols (HS (CH2) n X) on Au
(111) were used as substrates for crystallization of ferriprotoporphyrin IX (heme) in acidic …

Beneficial effect of aurothiomalate on murine malaria

I Alesutan, D Bobbala, SM Qadri, A Estremera, M Föller… - Malaria Journal, 2010 - Springer
Abstract Background Premature death of Plasmodium-infected erythrocytes is considered to
favourably influence the clinical course of malaria. Aurothiomalate has previously been …

Hemozoin: a case of heme crystal engineering

AN Hoang - 2010 - ir.vanderbilt.edu
During the pathogenic blood stage of a malaria infection, the Plasmodium parasites degrade
hemoglobin as a source of nutrition. As a consequence, free heme, known to be toxic to the …

Synthesen und Reaktionen von Heterocyclen mit Fluoreszenz-optischen Eigenschaften/vorgelegt von Guy Crépin Enoua

GC Enoua - unipub.uni-graz.at
Zusammenfassung Synthesen und Reaktionen von Heterocyclen mit Fluoreszenz-optischen
Eigenschaften GC ENOUA Carbostyrile haben in letzter Zeit großes Interesse als stabile …

Crystallization of Synthetic Hemozoin (Beta-Hematin) Nucleated at the Surface of Synthetic Neutral Lipid Bodies

TJ Egan, AN Hoang, KK Ncokazi… - MRS Online …, 2010 - cambridge.org
The mechanism of formation of hemozoin, a detoxification by-product of several blood-
feeding organisms including malaria parasites, has been a subject of debate; however …

Eryptosis as protection factor against malaria

D Bobbala - 2010 - ub01.uni-tuebingen.de
Over the past centuries malaria, a dreadful pathogen born blood related disease has been
the major cause of mortality among mankind. As time passed the pathogens coevolved with …