Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an appalling
prognosis. The failure of anti-inflammatory therapies coupled with the observation that …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …

NF-κB regulates the expression of a large number of target genes involved in the immune
and inflammatory response, apoptosis, cell proliferation, differentiation and survival. In this …

The transcription factor Oct4 is key in embryonic stem cell identity and reprogramming.
Insight into its partners should illuminate how the pluripotent state is established and …

The Myc oncoprotein family comprises transcription factors that control multiple cellular
functions and are widely involved in oncogenesis. Here we report the identification of Myc …

Protein acetylation has historically been considered a predominantly eukaryotic
phenomenon. Recent evidence, however, supports the hypothesis that acetylation broadly …

Regulatory machinery is focally organized in the interphase nucleus. The information
contained in these focal nuclear microenvironments must be inherited during cell division to …

Evidence suggesting that eukaryotes and archaea use reversible N ε-lysine (N ε-Lys)
acetylation to modulate gene expression has been reported, but evidence for bacterial use …

The TIP60 tumor suppressor is a histone acetyltransferase involved in transcriptional
regulation, checkpoint activation, and p53-directed proapoptotic pathways. We report that …

Maternal food restriction is associated with the development of obesity in offspring. This
study examined how maternal undernutrition in sheep affects the fetal hypothalamic …