Posttranscriptional regulation of cancer traits by HuR

K Abdelmohsen, M Gorospe - Wiley Interdisciplinary Reviews …, 2010 - Wiley Online Library
Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements

KSA Khabar - Cellular and molecular life sciences, 2010 - Springer
A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic …

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

DJ Hodson, ML Janas, A Galloway, SE Bell… - Nature …, 2010 - nature.com
Abstract ZFP36L1 and ZFP36L2 are RNA-binding proteins (RBPs) that interact with AU-rich
elements in the 3′ untranslated region of mRNA, which leads to mRNA degradation and …

Networks controlling mRNA decay in the immune system

J Schott, G Stoecklin - Wiley Interdisciplinary Reviews: RNA, 2010 - Wiley Online Library
The active control of mRNA degradation has emerged as a key regulatory mechanism
required for proper gene expression in the immune system. An adenosine/uridine (AU)‐rich …

Posttranscriptional regulation of TNF mRNA: a paradigm of signal-dependent mRNA utilization and its relevance to pathology

P Stamou, DL Kontoyiannis - TNF Pathophysiology, 2010 - karger.com
The relationship between TNF and immune pathology forced an intense research into the
regulation of its biosynthesis that extends to multiple mechanisms controlling the utilization …

FasL expression in activated T lymphocytes involves HuR-mediated stabilization

GL Drury, S Di Marco, V Dormoy-Raclet… - Journal of Biological …, 2010 - ASBMB
A prolonged activation of the immune system is one of the main causes of hyperproliferation
of lymphocytes leading to defects in immune tolerance and autoimmune diseases. Fas …

Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation

B Priyadharshini - 2010 - repository.escholarship.umassmed …
The instructive signals received by T cells during the programming stages of activation will
determine the fate of effector and memory populations generated during an immune …

Deletion of the RNA-binding proteins Zfp36l1 and Zfp36l2 leads to perturbed thymic development and T-lymphoblastic leukaemia.

M Turner, DJ Hodson, ML Janas, A Galloway… - Nature …, 2010 - hal.science
ZFP36L1 and ZFP36L2 are RNA-binding proteins (RBPs) which interact with AU-rich
elements in the 3'UTR of mRNA, leading to mRNA degradation and translational repression …

Expression, regulation and modulation of Fas Ligand during T lymphocyte activation

GL Drury - 2010 - escholarship.mcgill.ca
Expression, regulation and modulation of Fas Ligand during T lymphocyte activation Page 1
Expression, regulation and modulation of Fas Ligand during T lymphocyte activation Gillian …

T cell-specific NF-κB is necessary for islet allograft rejection

DL Porras - 2010 - search.proquest.com
Islet transplantation has the potential to cure Type 1 Diabetes (T1D), a chronic lifelong
disease. A major obstacle limiting its efficacy is allograft rejection. At present, many …