Origins and evolution of antibiotic resistance

J Davies, D Davies - Microbiology and molecular biology reviews, 2010 - Am Soc Microbiol
Antibiotics have always been considered one of the wonder discoveries of the 20th century.
This is true, but the real wonder is the rise of antibiotic resistance in hospitals, communities …

[PDF][PDF] Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis

H Tilg, AR Moschen - Hepatology, 2010 - Wiley Online Library
Whereas in most cases a fatty liver remains free of inflammation, 10%‐20% of patients who
have fatty liver develop inflammation and fibrosis (nonalcoholic steatohepatitis [NASH]) …

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

C De Filippo, D Cavalieri, M Di Paola… - Proceedings of the …, 2010 - National Acad Sciences
Gut microbial composition depends on different dietary habits just as health depends on
microbial metabolism, but the association of microbiota with different diets in human …

Genomics and the future of conservation genetics

FW Allendorf, PA Hohenlohe, G Luikart - Nature reviews genetics, 2010 - nature.com
We will soon have complete genome sequences from thousands of species, as well as from
many individuals within species. This coming explosion of information will transform our …

Intestinal goblet cells and mucins in health and disease: recent insights and progress

YS Kim, SB Ho - Current gastroenterology reports, 2010 - Springer
The mucus layer coating the gastrointestinal tract is the front line of innate host defense,
largely because of the secretory products of intestinal goblet cells. Goblet cells synthesize …

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

AK Benson, SA Kelly, R Legge, F Ma… - Proceedings of the …, 2010 - National Acad Sciences
In vertebrates, including humans, individuals harbor gut microbial communities whose
species composition and relative proportions of dominant microbial groups are …

Has the microbiota played a critical role in the evolution of the adaptive immune system?

YK Lee, SK Mazmanian - science, 2010 - science.org
Although microbes have been classically viewed as pathogens, it is now well established
that the majority of host-bacterial interactions are symbiotic. During development and into …

A window into third-generation sequencing

EE Schadt, S Turner, A Kasarskis - Human molecular genetics, 2010 - academic.oup.com
First-and second-generation sequencing technologies have led the way in revolutionizing
the field of genomics and beyond, motivating an astonishing number of scientific advances …

Long-term impacts of antibiotic exposure on the human intestinal microbiota

C Jernberg, S Lofmark, C Edlund… - Microbiology, 2010 - microbiologyresearch.org
Although it is known that antibiotics have short-term impacts on the human microbiome,
recent evidence demonstrates that the impacts of some antibiotics remain for extended …

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

EF Murphy, PD Cotter, S Healy, TM Marques… - Gut, 2010 - gut.bmj.com
Background and Aims Increased efficiency of energy harvest, due to alterations in the gut
microbiota (increased Firmicutes and decreased Bacteroidetes), has been implicated in …