Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis

V Chandran, SP Raychaudhuri - Journal of autoimmunity, 2010 - Elsevier
Psoriasis and Psoriatic Arthritis (PsA) are chronic inflammatory diseases that have a major
impact on health. The prevalence and incidence estimates of these two closely related …

Genome-wide association studies in diverse populations

NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

A Strange, F Capon, CCA Spencer, J Knight… - Nature …, 2010 - ncbi.nlm.nih.gov
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions
FC, ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

LD Sun, H Cheng, ZX Wang, AP Zhang, PG Wang… - Nature …, 2010 - nature.com
We extended our previous genome-wide association study for psoriasis with a multistage
replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from …

[HTML][HTML] Molecular dissection of psoriasis: integrating genetics and biology

JT Elder, AT Bruce, JE Gudjonsson, A Johnston… - Journal of Investigative …, 2010 - Elsevier
Psoriasis is a common and debilitating disease of the skin, nails, and joints, with an
acknowledged but complex genetic basis. Early genome-wide linkage studies of psoriasis …

Psoriasis genetics: breaking the barrier

EDO Roberson, AM Bowcock - Trends in Genetics, 2010 - cell.com
Psoriasis is a common incurable inflammatory skin disease affecting 2–3% of the European
population. Psoriatic skin contains large numbers of immune cells which produce many …

[HTML][HTML] Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models

JE Gudjonsson, J Ding, A Johnston, T Tejasvi… - Journal of Investigative …, 2010 - Elsevier
To further elucidate molecular alterations in psoriasis, we performed a gene expression
study of 58 paired lesional and uninvolved psoriatic and 64 control skin samples …

Psoriasis: what we have learned from mouse models

EF Wagner, HB Schonthaler… - Nature Reviews …, 2010 - nature.com
Psoriasis is a common inflammatory skin disease of unknown etiology, for which there is no
cure. This heterogeneous, cutaneous, inflammatory disorder is clinically characterized by …

Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohn's Disease

P Danoy, K Pryce, J Hadler, LA Bradbury, C Farrar… - PLoS …, 2010 - journals.plos.org
Ankylosing spondylitis (AS) is a common inflammatory arthritic condition. Overt inflammatory
bowel disease (IBD) occurs in about 10% of AS patients, and in addition 70% of AS cases …

Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

C Quan, YQ Ren, LH Xiang, LD Sun, AE Xu, XH Gao… - Nature …, 2010 - nature.com
We conducted a genome-wide association study of generalized vitiligo in the Chinese Han
population by genotyping 1,117 cases and 1,429 controls. The 34 most promising SNPs …