Genome-wide association studies in diverse populations

NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

Spatially explicit Bayesian clustering models in population genetics

O François, E Durand - Molecular Ecology Resources, 2010 - Wiley Online Library
This article reviews recent developments in Bayesian algorithms that explicitly include
geographical information in the inference of population structure. Current models …

[图书][B] Bourgeois dignity: Why economics can't explain the modern world

DN McCloskey - 2010 - books.google.com
The big economic story of our times is not the Great Recession. It is how China and India
began to embrace neoliberal ideas of economics and attributed a sense of dignity and …

The genome-wide structure of the Jewish people

DM Behar, B Yunusbayev, M Metspalu, E Metspalu… - Nature, 2010 - nature.com
Contemporary Jews comprise an aggregate of ethno-religious communities whose
worldwide members identify with each other through various shared religious, historical and …

Genome-wide patterns of population structure and admixture in West Africans and African Americans

K Bryc, A Auton, MR Nelson… - Proceedings of the …, 2010 - National Acad Sciences
Quantifying patterns of population structure in Africans and African Americans illuminates
the history of human populations and is critical for undertaking medical genomic studies on …

A worldwide correlation of lactase persistence phenotype and genotypes

Y Itan, BL Jones, CJE Ingram, DM Swallow… - BMC evolutionary …, 2010 - Springer
Background The ability of adult humans to digest the milk sugar lactose-lactase persistence-
is a dominant Mendelian trait that has been a subject of extensive genetic, medical and …

Complete Khoisan and Bantu genomes from southern Africa

SC Schuster, W Miller, A Ratan, LP Tomsho, B Giardine… - Nature, 2010 - nature.com
The genetic structure of the indigenous hunter-gatherer peoples of southern Africa, the
oldest known lineage of modern human, is important for understanding human diversity …

[PDF][PDF] Inferring genetic ancestry: opportunities, challenges, and implications

CD Royal, J Novembre, SM Fullerton… - The American Journal of …, 2010 - cell.com
Increasing public interest in direct-to-consumer (DTC) genetic ancestry testing has been
accompanied by growing concern about issues ranging from the personal and societal …

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

CG Bell, S Finer, CM Lindgren, GA Wilson, VK Rakyan… - PloS one, 2010 - journals.plos.org
Recent multi-dimensional approaches to the study of complex disease have revealed
powerful insights into how genetic and epigenetic factors may underlie their …

Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis

M Möller, EG Hoal - Tuberculosis, 2010 - Elsevier
The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of …