Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

Epigenetic modifications constitute a complex regulatory layer on top of the genome
sequence. Pluripotent and differentiated cells provide a powerful system for investigating …

DNA methylation plays an important role in biological processes in human health and
disease. Recent technological advances allow unbiased whole-genome DNA methylation …

Bisulfite sequencing measures absolute levels of DNA methylation at single-nucleotide
resolution, providing a robust platform for molecular diagnostics. We optimized bisulfite …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

Recent multi-dimensional approaches to the study of complex disease have revealed
powerful insights into how genetic and epigenetic factors may underlie their …

MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …