Ribosome biogenesis is a fundamental process that provides cells with the molecular
factories for cellular protein production. Accordingly, its misregulation lies at the heart of …

Ribosomes are vital for cell growth and survival. Until recently, it was believed that mutations
in ribosomes or ribosome biogenesis factors would be lethal, due to the essential nature of …

During translation, aminoacyl-tRNAs are delivered to the ribosome by specialized GTPases
called translation factors. Here, we report the tRNA binding to the P-site of 40 S ribosomes …

Understanding of eukaryotic ribosome synthesis has been slowed by a lack of structural
data for the pre‐ribosomal particles. We report rRNA‐binding sites for six late‐acting 40S …

The RNA-processing exosome contains ribonucleases that degrade aberrant RNAs in
archael and eukaryotic cells. In Saccharomyces cerevisiae, the nuclear/nucleolar 3′–5 …

Ribosome biogenesis is a highly regulated process ensuring that cell growth (increase in
biomass) is coordinated with cell proliferation. The formation of eukaryotic ribosomes is a …

Since their discovery in the mid-1990s, nuclear actin-related proteins (ARPs) have gained
attention for their roles as structural components of ATP-dependent chromatin-remodeling …

The small subunit (SSU) processome is a large ribonucleoprotein that is required for
maturation of the 18S rRNA of the ribosome. Recently, a missense mutation in the C …

The SSU processome is a large ribonucleoprotein complex consisting of the U3 snoRNA
and at least 43 proteins. A database search, initiated in an effort to discover additional SSU …

In budding yeast, the transcriptional machinery at tRNA genes naturally interferes with
replication in a way that can promote chromosome breakage. Here we show that a signaling …