Genomics, type 2 diabetes, and obesity
MI McCarthy - New England Journal of Medicine, 2010 - Mass Medical Soc
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Prioritizing GWAS results: a review of statistical methods and recommendations for their application
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …
disease gene discovery. A substantial number of recent GWAS indicate that for most …
METAL: fast and efficient meta-analysis of genomewide association scans
METAL provides a computationally efficient tool for meta-analysis of genome-wide
association scans, which is a commonly used approach for improving power complex traits …
association scans, which is a commonly used approach for improving power complex traits …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
EK Speliotes, CJ Willer, SI Berndt, KL Monda… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
LocusZoom: regional visualization of genome-wide association scan results
Genome-wide association studies (GWAS) have revealed hundreds of loci associated with
common human genetic diseases and traits. We have developed a web-based plotting tool …
common human genetic diseases and traits. We have developed a web-based plotting tool …
Biological, clinical and population relevance of 95 loci for blood lipids
TM Teslovich, K Musunuru, AV Smith, AC Edmondson… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …
(T2D) and 38,987 controls of European descent and following up previously unidentified …
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
K Musunuru, A Strong, M Frank-Kamenetsky, NE Lee… - Nature, 2010 - nature.com
Recent genome-wide association studies (GWASs) have identified a locus on chromosome
1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and …
1p13 strongly associated with both plasma low-density lipoprotein cholesterol (LDL-C) and …
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …