Dopamine and glutamate in Huntington's disease: a balancing act

VM André, C Cepeda, MS Levine - CNS neuroscience & …, 2010 - Wiley Online Library
Huntington's disease (HD) is caused by a CAG repeat expansion in exon 1 of the HD gene
resulting in a long polyglutamine tract in the N‐terminus of the protein huntingtin. Patients …

Differential vulnerability of neurons in Huntington's disease: the role of cell type‐specific features

I Han, YM You, JH Kordower, ST Brady… - Journal of …, 2010 - Wiley Online Library
J. Neurochem.(2010) 113, 1073–1091. Abstract Abnormal expansion of a polyglutamine
tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant …

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's …

J Miller, M Arrasate, BA Shaby, S Mitra… - Journal of …, 2010 - Soc Neuroscience
An expanded polyglutamine (polyQ) stretch in the protein huntingtin (htt) induces self-
aggregation into inclusion bodies (IBs) and causes Huntington's disease (HD). Defining …

Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium

BR Miller, I Bezprozvanny - Future neurology, 2010 - Taylor & Francis
Huntington's disease (HD) is a noncurable and progressive autosomal-dominant
neurodegenerative disorder that results from a polyglutamine expansion in the amino …

[图书][B] Estudio de las vías de supervivencia y muerte neuronal en modelos de la enfermedad de Huntington

P Paoletti Rubia - 2010 - diposit.ub.edu
[spa] En el desarrollo de esta tesis doctoral nos hemos centrado en el estudio de diferentes
vías de señalización intracelular implicadas en los procesos de supervivencia y muerte …

[图书][B] Molecular risk factors, cellular characteristics, and therapeutic approaches in Huntington's disease

JM Miller - 2010 - search.proquest.com
Abstract Huntington's disease (HD), an adult-onset, dominantly-inherited neurodegenerative
disease primarily affecting the striatum and deep cortical regions of the brain, is caused by a …